United begin their defence of the trophy at home to Roy Hodgson’s side, who are back at Old Trafford for the Premier League meeting between the two sides on Saturday.
Ten Hag is expected to make some changes to his side, having been hamstrung by a number of injuries in recent weeks with Mason Mount in the frame to return having been ruled out since late August.
Sofyan Amrabat, who joined the club on loan from Fiorentina during the final day of the summer transfer window, made a late cameo off the bench in the 1-0 win over Burnley on Saturday.
The Manchester Evening News report he is in line for a full debut against Palace with Casemiro among those who could be rested having started all seven of United’s matches this season.
Ten Hag could also use tonight’s fixture as an opportunity to hand a first appearance to goalkeeper Altay Bayindir.
The 25-year-old joined United from Fenerbache during the summer transfer window to serve as Andre Onana’s understudy.
The Cameroon international could miss as many as seven games for United in the New Year should his country progress well in the Africa Cup of Nations with ten Hag likely to be keen for Bayindir to get some game time before then.
Dan Gore is another who could be in line for his first-team debut.
The 19-year-old midfielder has been named on the bench in United’s last five games and could follow Hannibal Mejbri in being handed a first-team role, with the Tunisia international impressing against Burnley at the weekend.
In other possible changes, Alejandro Garnacho will hope for a runout against Palace.
The Argentina international started United’s first two games of the season but has managed just 12 minutes across three substitute appearances since the defeat to Tottenham.
For more stories like this, check our sport page.